The Renaissance produced many famous artworks that transformed Western art. **Leonardo da Vinci’s** *Mona Lisa* and *The Last Supper* are celebrated for their mastery of realism and human emotion. **Michelangelo’s** *David* and the ceiling of the Sistine Chapel demonstrate his exceptional skill in sculpture and painting, blending anatomy and spirituality. **Raphael’s** *The School of Athens* highlights Renaissance ideals of knowledge and harmony. **Botticelli’s** *The Birth of Venus* is renowned for its beauty and mythological themes. These artworks reflect the Renaissance’s focus on humanism, classical ideals, and innovations in perspective, anatomy, and composition.