Global pandemics have profoundly shaped human history by influencing societies, economies, and cultures. The **Black Death** (1347-1351) decimated Europe’s population, leading to economic shifts and changes in labor dynamics. The **Spanish Flu** (1918-1919) caused widespread illness and death, impacting global health policies and public health infrastructure. The COVID-19 pandemic (2019-present) accelerated digital transformation, highlighted healthcare disparities, and led to significant changes in work and social behaviors. Pandemics often prompt advancements in medicine, public health responses, and international cooperation while revealing vulnerabilities and inequalities within societies. Their long-term impacts continue to reshape historical and contemporary landscapes.