Environmental pollution is increasing gradually and causing a serious impact on living organisms including humans. It can be reduced by microorganisms or plants that have biosynthetic pathways for the degradation or accumulation of environmental pollutants from soil and water. Lack of genetic components in natural microorganisms or plants lessens their ability to degrade or accumulate pollutants and hence is currently released at high rates. Recent advances in CRISPR-Cas9 technology have been used to edit the genome of microorganisms or plants in order to improve the degradation and accumulation efficiency to a higher rate for controlling environmental pollutants.